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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can reduce panobinostat concentrations by ~70% and produce cure failure.pentobarbital will lessen the extent or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay c